Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.1
USERS' SCORE
Good
Based on 5 Reviews
8.5
Supplement Facts
Serving Size: 3 Capsules
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine hydrochloride)
10 mg
588%
Magnesium (as magnesium aspartate, magnesium oxide)
435 mg
104%
Zinc (as zinc aspartate, zinc monomethionine, zinc oxide)
28 mg
255%
Top Medical Research Studies
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
9
Zinc supplementation benefits MS models
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
Read More
Most Useful Reviews
9
Deep sleep
2 people found this helpful
A fantastic supplement; we sleep so soundly! This isn't my first order. We're very pleased with its effects. The recommended dosage for women is two capsules a day before bedtime. Both my mother, aged 70, and I, at 49, experience improved quality of sleep with deeper, more vivid dreams, reminiscent of childhood.
Read More
7.5
Restored sleep
1 people found this helpful
This supplement was effective for me. During my first bottle, I had no trouble sleeping and enjoyed quality rest. When I stopped taking it, I noticed the difference, returning to poor sleep with frequent awakenings. I regret halting my order and am now reordering.
Read More
9
Positive effect
Wonderful! The product met my expectations, was perfectly packaged, and its effects are undeniable! I will order more, and delivery was quick.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.1
- All Researches
9
We aimed to understand how high doses of vitamins B1, B6, and B12 might help improve vision in people suffering from relapsing-remitting multiple sclerosis (RRMS) who face persistent visual loss after acute optic neuritis. In our pilot study, we included sixteen patients who had been diagnosed with RRMS and had visual disabilities resulting from an earlier bout of optic neuritis. Each participant received a daily regimen of high-dose vitamins for 90 days, alongside their regular disease-modifying therapies.
Over the three-month follow-up, we noticed a significant improvement in visual acuity and foveal sensitivity threshold, suggesting that high doses of these B vitamins could play a role in enhancing visual function. The trends for other measures, such as mean deviation and pattern standard deviation in visual testing, were also promising. We found an interesting correlation: older patients had longer latency times in their visual processing but lower visual acuity at the follow-up. Crucially, we determined that the foveal sensitivity threshold was the main predictor of visual acuity improvement.
Although vitamin B6 was part of the combination treatment, it was challenging to pinpoint its individual effects. However, the collective results indicated that high-dose vitamin B treatment can be beneficial for visual function parameters in patients with MS-related visual issues.
Over the three-month follow-up, we noticed a significant improvement in visual acuity and foveal sensitivity threshold, suggesting that high doses of these B vitamins could play a role in enhancing visual function. The trends for other measures, such as mean deviation and pattern standard deviation in visual testing, were also promising. We found an interesting correlation: older patients had longer latency times in their visual processing but lower visual acuity at the follow-up. Crucially, we determined that the foveal sensitivity threshold was the main predictor of visual acuity improvement.
Although vitamin B6 was part of the combination treatment, it was challenging to pinpoint its individual effects. However, the collective results indicated that high-dose vitamin B treatment can be beneficial for visual function parameters in patients with MS-related visual issues.
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9
We investigated the potential benefits of a treatment composed of advanced glycation end products inhibitors, which included vitamin B6, on patients with rheumatoid arthritis (RA). The study focused on how this combination therapy could enhance endothelial function in individuals suffering from this autoimmune disorder.
In a controlled research setup, 24 patients experiencing active RA despite standard treatments were given an AGEs inhibitor containing vitamins and other compounds. Over 12 weeks, we monitored various health indicators, including inflammatory markers and measures of endothelial function.
The results were promising. We noticed significant improvements in endothelial function, as indicated by enhanced vasodilation measures. Additionally, levels of inflammatory markers like ESR and CRP decreased notably, along with reductions in RA activity scores.
While vitamin B6 is included in the treatment mix, the study highlights the collective impact of the entire formulation on managing RA symptoms. This indicates the potential role that AGEs inhibitors, with vitamin B6 among other ingredients, can play in treating this challenging condition.
In a controlled research setup, 24 patients experiencing active RA despite standard treatments were given an AGEs inhibitor containing vitamins and other compounds. Over 12 weeks, we monitored various health indicators, including inflammatory markers and measures of endothelial function.
The results were promising. We noticed significant improvements in endothelial function, as indicated by enhanced vasodilation measures. Additionally, levels of inflammatory markers like ESR and CRP decreased notably, along with reductions in RA activity scores.
While vitamin B6 is included in the treatment mix, the study highlights the collective impact of the entire formulation on managing RA symptoms. This indicates the potential role that AGEs inhibitors, with vitamin B6 among other ingredients, can play in treating this challenging condition.
Read More
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
9
We explored the potential of a new magnesium-aluminum layered double hydroxide combined with nano-ceria in treating rheumatoid arthritis (RA). This innovative therapy targets the unhealthy immune environment and the harmful buildup of hydrogen ions associated with RA. By neutralizing excess acidity, we observed improved immune responses, encouraging the body to heal damaged bones. This approach showed promising results in mice models, indicating it may be a viable future treatment for managing RA effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Deep sleep
2 people found this helpful
A fantastic supplement; we sleep so soundly! This isn't my first order. We're very pleased with its effects. The recommended dosage for women is two capsules a day before bedtime. Both my mother, aged 70, and I, at 49, experience improved quality of sleep with deeper, more vivid dreams, reminiscent of childhood.
Read More
7.5
Restored sleep
1 people found this helpful
This supplement was effective for me. During my first bottle, I had no trouble sleeping and enjoyed quality rest. When I stopped taking it, I noticed the difference, returning to poor sleep with frequent awakenings. I regret halting my order and am now reordering.
Read More
9
Positive effect
Wonderful! The product met my expectations, was perfectly packaged, and its effects are undeniable! I will order more, and delivery was quick.
Read More
9
Joint improvement
It's effective! My joints feel much better after using this product.
Read More
7.5
Improved health
1 people found this helpful
Health has improved; I've just ordered my second bottle. This product works and is affordable. My zinc and magnesium levels were lower than they should be 3 to 4 months ago, and taking these once daily has helped my levels increase, making me feel better.
Read More
Frequently Asked Questions
7.5
Restored sleep
1 people found this helpful
This supplement was effective for me. During my first bottle, I had no trouble sleeping and enjoyed quality rest. When I stopped taking it, I noticed the difference, returning to poor sleep with frequent awakenings. I regret halting my order and am now reordering.
7.5
Improved health
1 people found this helpful
Health has improved; I've just ordered my second bottle. This product works and is affordable. My zinc and magnesium levels were lower than they should be 3 to 4 months ago, and taking these once daily has helped my levels increase, making me feel better.
9
Deep sleep
2 people found this helpful
A fantastic supplement; we sleep so soundly! This isn't my first order. We're very pleased with its effects. The recommended dosage for women is two capsules a day before bedtime. Both my mother, aged 70, and I, at 49, experience improved quality of sleep with deeper, more vivid dreams, reminiscent of childhood.
9
Joint improvement
It's effective! My joints feel much better after using this product.
8
We explored the effects of vitamin B6 on inflammation, particularly in relation to autoimmune disorders. The study focused on macrophages, which play a crucial role in our immune response. It found that vitamin B6 can significantly reduce the buildup of a substance called sphingosine-1-phosphate (S1P) in a way that depends on an enzyme known as sphingosine-1-phosphate lyase (SPL).
By promoting the activity of SPL, vitamin B6 helps lower the level of S1P in macrophages, which leads to decreased expression of pro-inflammatory cytokines. This means that vitamin B6 can effectively suppress some key signaling pathways in the body that drive inflammation.
In terms of practical benefits, we observed that mice receiving vitamin B6 supplementation were protected from severe endotoxic shock, a condition often tied to autoimmune reactions. Furthermore, it was noted that vitamin B6 can slow the progression of experimental autoimmune encephalomyelitis, a model for studying multiple sclerosis in humans.
Overall, these findings suggest that vitamin B6 has a promising role in managing excessive inflammation associated with autoimmune disorders, providing valuable insights for potential clinical applications.
By promoting the activity of SPL, vitamin B6 helps lower the level of S1P in macrophages, which leads to decreased expression of pro-inflammatory cytokines. This means that vitamin B6 can effectively suppress some key signaling pathways in the body that drive inflammation.
In terms of practical benefits, we observed that mice receiving vitamin B6 supplementation were protected from severe endotoxic shock, a condition often tied to autoimmune reactions. Furthermore, it was noted that vitamin B6 can slow the progression of experimental autoimmune encephalomyelitis, a model for studying multiple sclerosis in humans.
Overall, these findings suggest that vitamin B6 has a promising role in managing excessive inflammation associated with autoimmune disorders, providing valuable insights for potential clinical applications.
8
Vitamin B6 improves cognitive function
We conducted an intriguing study that looked into how vitamin B6 affects cognitive function in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD). This autoimmune disorder often brings along cognitive challenges, so understanding potential dietary influences could be beneficial.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
References
- Du X, Yang Y, Zhan X, Huang Y, Fu Y, et al. Vitamin B6 prevents excessive inflammation by reducing accumulation of sphingosine-1-phosphate in a sphingosine-1-phosphate lyase-dependent manner. J Cell Mol Med. 2020;24:13129. doi:10.1111/jcmm.15917
- Mallone F, Lucchino L, Franzone F, Marenco M, Carlesimo SC, et al. High-dose vitamin B supplementation for persistent visual deficit in multiple sclerosis: a pilot study. Drug Discov Ther. 2020;14:122. doi:10.5582/ddt.2020.03031
- Rezaeimanesh N, Saeedi R, Sahraian MA, Razeghi Jahromi S, Naser Moghadasi A. The possible beneficial effects of higher vitamin B6 intake from diet on cognitive function of patients with neuromyelitis optica spectrum disorder. Mult Scler Relat Disord. 2020;42:102132. doi:10.1016/j.msard.2020.102132
- Sande JS, Ulvik A, Midttun Ø, Ueland PM, Hammer HB, et al. Vitamin B-6 Status Correlates with Disease Activity in Rheumatoid Arthritis Patients During Treatment with TNFα Inhibitors. J Nutr. 2019;149:770. doi:10.1093/jn/nxz001
- Syngle A, Vohra K, Garg N, Kaur L, Chand P. Advanced glycation end-products inhibition improves endothelial dysfunction in rheumatoid arthritis. Int J Rheum Dis. 2012;15:45. doi:10.1111/j.1756-185X.2011.01679.x
- Toaima DN, Abdel-Maksoud KS, Atef HM, Salah NY. Magnesium, fibrinolysis and clotting interplay among children and adolescents with type 1 diabetes mellitus; potential mediators of diabetic microangiopathy. Nutr Diabetes. 2025;15:13. doi:10.1038/s41387-025-00368-9
- Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. doi:10.3390/nu16234247
- Fu C, Huang L, Lian C, Yue J, Lin P, et al. Effects of long-term magnesium L-threonate supplementation on neuroinflammation, demyelination and blood-brain barrier integrity in mice with neuromyelitis optica spectrum disorder. Brain Res. 2025;1846:149234. doi:10.1016/j.brainres.2024.149234
- Yan Y, Yao C, Zhang B, Yang Z, Xie J, et al. Olanzapine vs. magnesium valproate vs. lamotrigine in anti-N-methyl-D-aspartic acid receptor encephalitis: a retrospective study. BMC Neurol. 2024;24:331. doi:10.1186/s12883-024-03811-z
- Verlato A, Laragione T, Bin S, Kim RH, Salem F, et al. Revised version with tracked changes oral Magnesium reduces levels of pathogenic autoantibodies and skin disease in murine lupus. BMC Immunol. 2024;25:58. doi:10.1186/s12865-024-00650-y
- Liu H, Zhang K, Xiong L. Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database. J Health Popul Nutr. 2024;43:112. doi:10.1186/s41043-024-00597-1
- Fu H, Guo Y, Fang W, Wang J, Hu P, et al. Anti-Acidification and Immune Regulation by Nano-Ceria-Loaded Mg-Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy. Adv Sci (Weinh). 2024;11:e2307094. doi:10.1002/advs.202307094
- Fang J, Cao T, Liu C, Wang D, Zhang H, et al. Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES). BMC Public Health. 2023;23:2085. doi:10.1186/s12889-023-16906-y
- Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, et al. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023;92:104603. doi:10.1016/j.ebiom.2023.104603
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y
- Shao Y, Mu Q, Wang R, Luo H, Song Z, et al. SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease. Sci China Life Sci. 2025. doi:10.1007/s11427-024-2817-y
- Chen L, Yan C, Huang C, Jiang Z, Lin R, et al. Higher dietary zinc intake increases the risk of autoimmune thyroiditis. Postgrad Med J. 2025. doi:10.1093/postmj/qgae202
- Wu R, Li Y, Peng H, Yang Z, Wang Y, et al. Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025;24:e16740. doi:10.1111/jocd.16740
- Bayiroglu AF, Acar G, Gulbahce-Mutlu E, Baltaci SB, Mogulkoc R, et al. Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model. J Trace Elem Med Biol. 2024;86:127540. doi:10.1016/j.jtemb.2024.127540
- Fang D, Jiang D, Shi G, Song Y. The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2024;25:710. doi:10.1186/s12891-024-07768-5
- Cheng J, Rink L, Wessels I. Zinc Supplementation Reduces the Formation of Neutrophil Extracellular Traps by Decreasing the Expression of Peptidyl Arginine Deiminase 4. Mol Nutr Food Res. 2024;68:e2400013. doi:10.1002/mnfr.202400013
